Improving drug solubility is one of the biggest challenges for pharmaceutical companies as they are always looking for new strategies to increase bioavailability of new drugs. The development of amorphous solid dispersions is one highly successful way drug manufacturers have addressed this issue. Furthermore, utilizing silicates in this process is one aspect which can provide successful results.

In response, we want to share a presentation deck titled “Silicates as a Potential Amorphous Drug Delivery System” from Deepak Bahl at Merck. This presentation discusses silicates as a potential amorphous drug delivery system, key aspects of co-processing with silicates, mechanisms of stabilization of co-processed amorphous solids and factors affecting dissolution/solubility enhancement and the underlying mechanisms. It also examines bioavailability enhancement with silicates, recent advancements and future research focus.

Scroll through the presentation below……