Historically, oral administration has been considered the easiest and most convenient method of drug delivery, as it requires minimal expertise and invasiveness. Although oral delivery works fairly effectively for small-molecule drug products, oral delivery of macromolecules (particularly proteins and peptides) has been more challenging. Given the increase in biologics over the last decade, injection and infusion have been the chosen choices of delivery to overcome this issue. However, there is much need to find and develop new materials to overcome the physiological challenges of oral delivery for macromolecular agents, including the importance of protease inhibitors, designed to treat HIV – Protease inhibitors work by blocking the activity of HIV protease. . 

This week’s available deck is titled “Structure-guided Discovery of Solid Forms to Drive Oral Bioavailability of Protease Inhibitors” from Phil Snyder and Setu Roday at Vertex Pharmaceuticals. Phil presented this approach at our 2020 Global Drug Bioavailability Enhancement Summit in New York. This presentation explores integrating research & development to accelerate clinical evaluation of medicines, it explores the mechanisms of insolubility and enabling molecules with potential and discusses opportunities to influence decision-making in pre-development. 

Would you like to learn new strategies to improve patient compliance, bioavailability, stability and efficacy, all while reducing dosage, cost and decreasing time-to-market?

Join the drug development industry’s leading drug development specialists this March at the 2021 Global Drug Bioavailability Enhancement Summit in San Diego (March 3-4, 2021). Hear from 30+ senior drug bioavailability pioneers and network with 120+ senior drug development innovators and walk away with over 2 years of new drug formulation and bioavailability enhancement approaches strategies in just 2 days!

  • 30+ industry-led speaker faculty over 2 full days sharing innovative drug development take-home strategies
  • 12+ hours of networking sessions and breaks over two full days to learn from network with pharmaceutical and biotech senior formulation, development and delivery professionals
  • 120+ senior participants spanning pharma, biotech and specialty delivery & technology companies
  • Dynamic Tech Showcase Hall with multiple leading manufacturing, formulation development, delivery and modeling experts


Additionally, join nearly 1400 senior drug product development professionals in our free Novel Drug Discovery & Development Group. Members of this rapidly growing group will benefit by gaining access to an exclusive network of industry and academic professionals within the drug development arena. Members specialize in discovery, development, formulation, delivery and commercialization of innovative drug products.

Want to hear multiple weekly drug product development strategies and approaches from leading organizations and experts? Subscribe here and receive new podcast episodes, presentations, white papers, tips and resources directly from Curtis & Coulter weekly to your inbox

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