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Historically, oral administration has been considered the easiest and most convenient method of drug delivery, as it requires minimal expertise and invasiveness. Although oral delivery works fairly effectively for small-molecule drug products, oral delivery of macromolecules (particularly proteins and peptides) has been more challenging. Given the increase in biologics over the last decade, injection and infusion have been the chosen choices of delivery to overcome this issue. However, there is much need to find and develop new materials to overcome the physiological challenges of oral delivery for macromolecular agents, including the importance of protease inhibitors, designed to treat HIV – Protease inhibitors work by blocking the activity of HIV protease. . 

This week’s available deck is titled “Structure-guided Discovery of Solid Forms to Drive Oral Bioavailability of Protease Inhibitors” from Phil Snyder and Setu Roday at Vertex Pharmaceuticals. Phil presented this approach at our 2020 Global Drug Bioavailability Enhancement Summit in New York. This presentation explores integrating research & development to accelerate clinical evaluation of medicines, it explores the mechanisms of insolubility and enabling molecules with potential and discusses opportunities to influence decision-making in pre-development. 

2024 Controlled & Modified Drug Release Summit

(May 14-15, 2024, Princeton, NJ)


Interested to improve the performance of your drug products? Learn 2 years of new drug product development approaches at the 2024 Summit this coming May both in-person & virtual.

Join 160+ leading drug delivery, formulation and development experts and hear 30+ expert sessions. Gain over 2 years worth of new drug product development strategies, formulation approaches, delivery technologies and regulatory updates while decreasing drug product time-to-market in just 2 short days (all available on-demand)!

Save up-to 45% on attendance before Friday 29th September, 2023. Likewise, have a platform technology you would like to explore showcasing to the wider audience this May? Reach out below to find out remaining opportunities.

2021 On-Demand Summits Available for Purchase

(Limited time - Only $299)

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