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A prodrug is a medication or compound that metabolizes into a pharmacologically active drug after administration, offering opportunities to optimize the pharmaceutical property to improve bioavailability. Approximately 10% of all marketed drugs worldwide can be considered prodrugs. However, there are challenges for developing prodrugs.

The therapeutic rationale of a prodrug is to improve the physicochemical, biopharmaceutical, or pharmacokinetic properties of an active pharmaceutical ingredient (API). Key properties that prodrugs seek to modify generally fall within one or more of the ADME categories (Absorption, Distribution, Metabolism, and Excretion) with the end goal being the creation of a new chemical entity (NCE) that optimizes the performance, utility, and potential life-cycle management of the parent drug.

This week’s shared presentation is titled “A Prodrug Approach for Improving Bioavailability” from Dedong Wu at AstraZeneca. Dedong delivered this talk at our past Global Drug Bioavailability Summits earlier this year. This deck will give a brief introduction of the prodrug concept, intrinsic solubility improvement by prodrugs, as well as permeability enhancement by prodrugs. It additionally discusses in vivo molecule stability optimization by prodrugs and perspectives of prodrug design with examples. Scroll through the presentation below…

Are you looking to improve the performance of your drug products?

Consider joining industry’s leading drug development specialists this February at the 2020 Controlled & Modified Drug Release Virtual Summit. Hear from 30+ senior drug development and network with 100’s of senior drug development innovators and walk away with multiple new drug formulation and development approaches strategies in just 2 short days.

2021’s Summit will bring together key decision makers and innovators within this rapidly growing field. By attending this unique event, you will learn directly from industry’s leading experts and hear unique case study sessions and take-home examples to enhance your product pipeline. Gather insights into the latest technologies and methods in improving drug release mechanisms, maximizing exposure, and reducing time-to-market. Additionally, this must-attend event will showcase the latest regulatory guidance updates and the implications for the industry.

Register before 5PM ET Friday 15th January, 2021 to take advantage of early-bird pricing before it expires (save 41%).

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