Modeling and simulation of oral drug absorption are widely used in discovery, development, and regulation of drug product development. Predictive absorption models are used to determine the rate and extent of oral drug absorption, facilitate lead drug candidate selection, establish formulation development strategy, and support the development of regulatory policies. The Biopharmaceutics Classification System (BCS) of drugs provides information relevant to understanding and predicting GI drug absorption and bioavailability in general that is also relevant to the absorption potential for the colon. Drug performance is important to understand from a multitude of aspects including dosing, delivery mechanism, formulation, adherence and more. There are many approaches being developed to predict drug performance in the GI tract: each with it’s strengths and limitations.
This week’s available deck is titled “Evaluating the Utility of Gastrointestinal Systems in Predicting Drug Performance: Focus on Tiny-TIM” from Karthik Nagapudi at Genentech. Karthik was a past speaker at our Global Drug Bioavailability Enhancement Summit. This presentation overviews dissolution methodologies, the Tiny-TIM system, Tiny-TIM powder in capsule (PIC): Non-PPI vs PPIDdata and integrated Tiny-Tim and PK modeling approaches. It additionally shares case studies including decreased bioavailability of GDC-A in patients taking PPI amongst others, as well as discussing what Tiny-TIM tells us about the formulation fix.
Would you like to learn new strategies to improve patient compliance, bioavailability, stability and efficacy, all while reducing dosage, cost and decreasing time-to-market?
Join the drug development industry’s leading drug development specialists this March at the 2021 Global Drug Bioavailability Enhancement Summit in San Diego (March 3-4, 2021). Hear from 30+ senior drug bioavailability pioneers and network with 120+ senior drug development innovators and walk away with over 2 years of new drug formulation and bioavailability enhancement approaches strategies in just 2 days!
- 30+ industry-led speaker faculty over 2 full days sharing innovative drug development take-home strategies
- 12+ hours of networking sessions and breaks over two full days to learn from network with pharmaceutical and biotech senior formulation, development and delivery professionals
- 120+ senior participants spanning pharma, biotech and specialty delivery & technology companies
- Dynamic Tech Showcase Hall with multiple leading manufacturing, formulation development, delivery and modeling experts
Additionally, join over 1350 senior drug product development professionals in our free Novel Drug Discovery & Development Group. Members of this rapidly growing group will benefit by gaining access to an exclusive network of industry and academic professionals within the drug development arena. Members specialize in discovery, development, formulation, delivery and commercialization of innovative drug products.
Want to hear multiple weekly drug product development strategies and approaches from leading organizations and experts? Subscribe here and receive new podcast episodes, presentations, white papers, tips and resources directly from Curtis & Coulter weekly to your inbox